Healthy red blood cells owe their shape to muscle-like structures

Journal of Blood Research & Hematologic Diseases is an open access journal and celebrating the 5th Anniversary, an esteemed journal which mainly deals with Blood Research & Hematologic Diseases.
This Journal of Blood Research & Hematologic Diseases is a peer reviewing processing journal and publishes the articles on Blood Vessels, Circulatory System, Haematology, Haematopoiesis, Haemoglobin, Haemostasis
Red blood cells are on a wild ride. As they race through the body to deliver oxygen, they must maintain a distinct dimpled shape—and bounce back into form even after squishing through narrow capillaries. Red blood cells that can’t keep their shape are associated with diseases like sickle cell anemia.
“Red blood cells have been studied for centuries, but there are still a lot of unanswered questions about how they adopt their shape,” says Alyson Smith, graduate student at Scripps Research and co-first author of the study. “Our study adds an important piece to this puzzle.”
Red blood cells look like puffy disks with concave “dimples” on top and bottom. But the blood cells of people with certain disorders take on other shapes. In severe forms of sickle cell diseases, genetic disorders most common among people of African descent, the cells are shaped like crescent moons or sickles.
These misshapen cells are rigid and sticky, causing them to become stuck in blood vessels, which prevent the blood from carrying oxygen throughout the body, causing anemia. About 300,000 children are born with sickle cell anemia each year, and there is currently no cure for these disorders.
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